Article
Molecular heterogeneity of head and neck squamous cell carcinoma defined by next-generation sequencing.
The American journal of pathology - 1 May 2014
Zhang Pan, Mirani Neena, Baisre Ada, Fernandes Helen
Abstract excerpt
Head and neck squamous cell carcinoma (HNSCC) can be divided into two different clinical entities based on their association with high-risk subtypes of human papilloma virus (HPV16 and HPV18). Dissimilarities in prognosis and molecular profiles have attracted much attention in recent years, in part because of increasing rates of HPV infection in HNSCC; however, the underlying mechanisms and detailed genetic...
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