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Article

The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.

Human molecular genetics - 15 Oct 2018

Dahoun Tarik, Pardiñas Antonio F, Veronese Mattia, Bloomfield Michael A P, Jauhar Sameer, Bonoldi Ilaria, Froudist-Walsh Sean, Nosarti Chiara, Korth Carsten, Hennah William, Walters James, Prata Diana, Howes Oliver D

Abstract excerpt

Whilst the role of the Disrupted-in-Schizophrenia 1 (DISC1) gene in the aetiology of major mental illnesses is debated, the characterization of its function lends it credibility as a candidate. A key aspect of this functional characterization is the determination of the role of common non-synonymous polymorphisms on normal variation within these functions. The common allele (A) of the DISC1 single-nucleotide...

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Identifiers

PMID: 29945223
DOI: 10.1093/hmg/ddy242
PMCID: PMC6168972

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DISC1

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The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.PMID 29945223Read ↗

Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.Semantic proximity Read ↗

Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling.Semantic proximity Read ↗

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Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.Semantic proximity Read ↗

DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.Semantic proximity Read ↗

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