Article
The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity.
Molecular brain - 3 Jun 2020
Su Ping, Zhang Hailong, Wong Albert H C, Liu Fang
Abstract excerpt
The Disrupted in schizophrenia 1 (DISC1) gene encodes a scaffolding protein that is involved in many neural functions such as neurogenesis, neural differentiation, embryonic neuron migration and neurotransmitter signalling. DISC1 was originally implicated in schizophrenia in a single family with a drastic mutation, a chromosomal translocation severing the mid-point of the gene (aa 598). Some common DISC1 variants...
Topics
- Animals
- Glycogen Synthase Kinase 3
- HEK293 Cells
- Humans
- Mice
- Mutation
- Nerve Tissue Proteins
- Phosphorylation
- Phosphoserine
- Receptors, Dopamine D2