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Article

Mutual regulation of spermatogenesis-specific Argonaute proteins and Insulin/IGF-1 signaling in aging control.

EMBO reports - 1 Mar 2026

Liontis Thomas, Pannarale Valentina T, Mansisidor Andrés R, Pathiranage Sasiru K, Patel Jeeya Y, Grishok Alla

Abstract excerpt

The potential role of small interfering RNAs (siRNAs) produced from double-stranded RNA in aging has not been fully addressed. The networks of genes regulated by siRNAs and their partner Argonaute proteins are best understood in C. elegans, a pioneering model of aging and small RNA studies. Here, we describe synergistic lifespan extension of insulin/IGF-1 signaling (IIS) mutant age-1(hx546) by rde-4 or alg-3;...

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Identifiers

PMID: 41507348
DOI: 10.1038/s44319-025-00682-4
PMCID: PMC13021995

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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