Article

A single nonsynonymous mutation on gene encoding E protein of Zika virus leads to increased neurovirulence <i>in vivo</i>

2020-01-20

Abstract excerpt

Zika virus can infect a wide range of tissues including the developmental brain of human fetuses, causing from mild to severe clinical diseases. Whether its genetic characteristics impacts on viral pathogenesis is incompletely understood. We have obtained viral variants through serially passage of a clinical Zika virus isolate (SW01) in neonatal mice in vivo and found some of which exhibited markedly increased vi...

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Literature Corpus work: fe2a355a-231b-5dec-b298-0ff25f961939
DOI: 10.1101/2020.01.20.912535

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