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Article

A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host.

Proceedings of the National Academy of Sciences of the United States of America - 19 Oct 2021

Yu Xi, Shan Chao, Zhu Yibin, Ma Enhao, Wang Jinglin, Wang Penghua, Shi Pei-Yong, Cheng Gong

Abstract excerpt

Zika virus (ZIKV) caused millions of infections during its rapid and expansive spread from Asia to the Americas from 2015 to 2017. Here, we compared the infectivity of ZIKV mutants with individual stable substitutions which emerged throughout the Asian ZIKV lineage and were responsible for the explosive outbreaks in the Americas. A threonine (T) to alanine (A) mutation at the 106th residue of the ZIKV capsid (C)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34620704
DOI: 10.1073/pnas.2113015118
PMCID: PMC8545446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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