Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A single nonsynonymous mutation on ZIKV E protein-coding sequences leads to markedly increased neurovirulence in vivo.

Virologica Sinica - 1 Feb 2022

Liu Zhihua, Zhang Yawei, Cheng Mengli, Ge Ningning, Shu Jiayi, Xu Zhiheng, Su Xiao, Kou Zhihua, Tong Yigang, Qin Chengfeng, Jin Xia

Abstract excerpt

Zika virus (ZIKV) can infect a wide range of tissues including the developmental brain of human fetus. Whether specific viral genetic variants are linked to neuropathology is incompletely understood. To address this, we have intracranially serially passaged a clinical ZIKV isolate (SW01) in neonatal mice and discovered variants that exhibit markedly increased virulence and neurotropism. Deep sequencing analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytopathogenic Effect, Viral
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mosquito-borne diseases and control

Share to Mutation

Share to Viral Infections and Vectors

Share to Virulence

Share to Zika Virus

Share to Zika Virus Infection

Source

Open in PubMed Open full text

Identifiers

PMID: 35234632
DOI: 10.1016/j.virs.2022.01.021
PMCID: PMC8922429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single nonsynonymous mutation on ZIKV E protein-coding sequences leads to markedly increased neurovirulence in vivo.PMID 35234632Read ↗

A single nonsynonymous mutation on gene encoding E protein of Zika virus leads to increased neurovirulence <i>in vivo</i>Semantic proximity Read ↗

A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotypeSemantic proximity Read ↗

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly.Semantic proximity Read ↗

Contributions of Genetic Evolution to Zika Virus EmergenceSemantic proximity Read ↗

The Evolving Role of Zika Virus Envelope Protein in Viral Entry and PathogenesisSemantic proximity Read ↗

Zika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated and Defective in Neuroinvasion.Semantic proximity Read ↗

Probing Molecular Insights into Zika Virus–Host InteractionsSemantic proximity Read ↗

A natural polymorphism in Zika virus NS2A protein responsible of virulence in miceSemantic proximity Read ↗

An Overview of Zika Virus and Zika Virus Induced NeuropathiesSemantic proximity Read ↗

De Novo Generation and Characterization of New Zika Virus Isolate Using Sequence Data from a Microcephaly CaseSemantic proximity Read ↗

Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous SystemSemantic proximity Read ↗

Deep Mutational Scanning Comprehensively Maps How Zika Envelope Protein Mutations Affect Viral Growth and Antibody EscapeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.