Article
Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance.
eLife - 12 May 2020
Mathieu Luana C, Cox Horace, Early Angela M, Mok Sachel, Lazrek Yassamine, Paquet Jeanne-Celeste, Ade Maria-Paz, Lucchi Naomi W, Grant Quacy, Udhayakumar Venkatachalam, Alexandre Jean Sf, Demar Magalie, Ringwald Pascal, Neafsey Daniel E, Fidock David A, Musset Lise
Abstract excerpt
Antimalarial drug resistance has historically arisen through convergent de novo mutations in Plasmodium falciparum parasite populations in Southeast Asia and South America. For the past decade in Southeast Asia, artemisinins, the core component of first-line antimalarial therapies, have experienced delayed parasite clearance associated with several pfk13 mutations, primarily C580Y. We report that mutant pfk13 has...
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