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Article

Pooled sequencing and rare variant association tests for identifying the determinants of emerging drug resistance in malaria parasites.

Molecular biology and evolution - 1 Apr 2015

Cheeseman Ian H, McDew-White Marina, Phyo Aung Pyae, Sriprawat Kanlaya, Nosten François, Anderson Timothy J C

Abstract excerpt

We explored the potential of pooled sequencing to swiftly and economically identify selective sweeps due to emerging artemisinin (ART) resistance in a South-East Asian malaria parasite population. ART resistance is defined by slow parasite clearance from the blood of ART-treated patients and mutations in the kelch gene (chr. 13) have been strongly implicated to play a role. We constructed triplicate pools of 70...

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PMID: 25534029
DOI: 10.1093/molbev/msu397
PMCID: PMC4379400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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