Article
Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea.
PLoS pathogens - 1 Dec 2020
Miotto Olivo, Sekihara Makoto, Tachibana Shin-Ichiro, Yamauchi Masato, Pearson Richard D, Amato Roberto, Gonçalves Sonia, Mehra Somya, Noviyanti Rintis, Marfurt Jutta, Auburn Sarah, Price Ric N, Mueller Ivo, Ikeda Mie, Mori Toshiyuki, Hirai Makoto, Tavul Livingstone, Hetzel Manuel W, Laman Moses, Barry Alyssa E, Ringwald Pascal, Ohashi Jun, Hombhanje Francis, Kwiatkowski Dominic P, Mita Toshihiro
Abstract excerpt
The rapid and aggressive spread of artemisinin-resistant Plasmodium falciparum carrying the C580Y mutation in the kelch13 gene is a growing threat to malaria elimination in Southeast Asia, but there is no evidence of their spread to other regions. We conducted cross-sectional surveys in 2016 and 2017 at two clinics in Wewak, Papua New Guinea (PNG) where we identified three infections caused by C580Y mutants among...
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