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Article

Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction.

Nature communications - 1 Jan 2013

Anastasia Agustin, Deinhardt Katrin, Chao Moses V, Will Nathan E, Irmady Krithi, Lee Francis S, Hempstead Barbara L, Bracken Clay

Abstract excerpt

A common single-nucleotide polymorphism (SNP) in the human brain-derived neurotrophic factor (BDNF) gene results in a Val66Met substitution in the BDNF prodomain region. This SNP is associated with alterations in memory and with enhanced risk to develop depression and anxiety disorders in humans....

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Identifiers

PMID: 24048383
DOI: 10.1038/ncomms3490
PMCID: PMC3820160

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24048383-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction.PMID 24048383Read ↗

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Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons.Semantic proximity Read ↗

The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior.Semantic proximity Read ↗

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