Article
Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood.
Molecular psychiatry - 1 Jul 2006
Glorioso C, Sabatini M, Unger T, Hashimoto T, Monteggia L M, Lewis D A, Mirnics K
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) has been reported to be critical for the development of cortical inhibitory neurons. However, the effect of BDNF on the expression of transcripts whose protein products are involved in gamma amino butric acid (GABA) neurotransmission has not been assessed. In this study, gene expression profiling using oligonucleotide microarrays was performed in prefrontal cortical tissue...
Topics
- Animals
- Brain Diseases
- Brain-Derived Neurotrophic Factor
- Crosses, Genetic
- Doxycycline
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- Genes, Immediate-Early
- Humans
- Immediate-Early Proteins
- Interneurons
- Intracellular Signaling Peptides and Proteins