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Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis

1 Jun 2018

Abstract excerpt

Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, provide opportunities for the molecular analysis of tumors. We have now analyzed DNA methylation patterns in colorectal adenomas and identified three biologically defined...

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PMID: 29898408
DOI: 10.1016/j.celrep.2018.05.045

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