Colorectal cancer: epigenetic alterations and their clinical implications.

doi:10.1016/j.bbcan.2017.09.003

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Article

Colorectal cancer: epigenetic alterations and their clinical implications.

Biochimica et biophysica acta. Reviews on cancer - 1 Dec 2017

Puccini Alberto, Berger Martin D, Naseem Madiha, Tokunaga Ryuma, Battaglin Francesca, Cao Shu, Hanna Diana L, McSkane Michelle, Soni Shivani, Zhang Wu, Lenz Heinz-Josef

Abstract excerpt

Colorectal cancer (CRC) is a heterogeneous disease with distinct molecular and clinical features, which reflects the wide range of prognostic outcomes and treatment responses observed among CRC patients worldwide. Our understanding of the CRC epigenome has been largely developed over the last decade and it is now believed that among thousands of epigenetic alterations present in each tumor, a small subgroup of...

Topics

Chromosomal Instability
Colorectal Neoplasms
CpG Islands
DNA Methylation
Humans
MicroRNAs
Microsatellite Instability
Phenotype

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Identifiers

PMID: 28939182
DOI: 10.1016/j.bbcan.2017.09.003
PMCID: PMC5757873

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