Article
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.
Nature medicine - 1 May 2013
De Sousa E Melo Felipe, Wang Xin, Jansen Marnix, Fessler Evelyn, Trinh Anne, de Rooij Laura P M H, de Jong Joan H, de Boer Onno J, van Leersum Ronald, Bijlsma Maarten F, Rodermond Hans, van der Heijden Maartje, van Noesel Carel J M, Tuynman Jurriaan B, Dekker Evelien, Markowetz Florian, Medema Jan Paul, Vermeulen Louis
Abstract excerpt
Colon cancer is a clinically diverse disease. This heterogeneity makes it difficult to determine which patients will benefit most from adjuvant therapy and impedes the development of new targeted agents. More insight into the biological diversity of colon cancers, especially in relation to clinical features, is therefore needed. We demonstrate, using an unsupervised classification strategy involving over 1,100...
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