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Article

Gene-environment interactions in case-control studies with silent disease.

Genetic epidemiology - 1 Sept 2018

Lobach Iryna, Sampson Joshua, Lobach Siarhei, Zhang Li

Abstract excerpt

Genome-wide association studies (GWAS) often measure gene-environment interactions (G × E). We consider the problem of accurately estimating a G × E in a case-control GWAS when a subset of the controls have silent, or undiagnosed, disease and the frequency of the silent disease varies by the environmental variable. We show that using case-control status without accounting for misdiagnosis can lead to biased...

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PMID: 29896809
DOI: 10.1002/gepi.22135
PMCID: PMC6237277

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