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Article

Environmental confounding in gene-environment interaction studies.

American journal of epidemiology - 1 Jul 2013

Vanderweele Tyler J, Ko Yi-An, Mukherjee Bhramar

Abstract excerpt

We show that, in the presence of uncontrolled environmental confounding, joint tests for the presence of a main genetic effect and gene-environment interaction will be biased if the genetic and environmental factors are correlated, even if there is no effect of either the genetic factor or the environmental factor on the disease. When environmental confounding is ignored, such tests will in fact reject the joint...

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Identifiers

PMID: 23821317
DOI: 10.1093/aje/kws439
PMCID: PMC3698991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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