Article
Estimation and testing of gene-environment interactions in family-based association studies.
Genomics - 1 Jan 2009
Cordell Heather J
Abstract excerpt
Gene-environment interactions are of interest in genetic association studies for several reasons. First, the power to detect genetic effects may be substantially decreased if those effects differ according to environmental exposure and if no account is taken of this interaction with environmental exposure in the analysis. Second, such interactions may indicate a phenomenon of genuine biological interest (whereby...
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