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Article

Accounting for Population Structure in Gene-by-Environment Interactions in Genome-Wide Association Studies Using Mixed Models.

PLoS genetics - 1 Mar 2016

Sul Jae Hoon, Bilow Michael, Yang Wen-Yun, Kostem Emrah, Furlotte Nick, He Dan, Eskin Eleazar

Abstract excerpt

Although genome-wide association studies (GWASs) have discovered numerous novel genetic variants associated with many complex traits and diseases, those genetic variants typically explain only a small fraction of phenotypic variance. Factors that account for phenotypic variance include environmental factors and gene-by-environment interactions (GEIs). Recently, several studies have conducted genome-wide...

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Identifiers

PMID: 26943367
DOI: 10.1371/journal.pgen.1005849
PMCID: PMC4778803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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