Article
Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides.
Nature communications - 9 Apr 2014
Granados Diana Paola, Sriranganadane Dev, Daouda Tariq, Zieger Antoine, Laumont Céline M, Caron-Lizotte Olivier, Boucher Geneviève, Hardy Marie-Pierre, Gendron Patrick, Côté Caroline, Lemieux Sébastien, Thibault Pierre, Perreault Claude
Abstract excerpt
For decades, the global impact of genomic polymorphisms on the repertoire of peptides presented by major histocompatibility complex (MHC) has remained a matter of speculation. Here we present a novel approach that enables high-throughput discovery of polymorphic MHC class I-associated peptides (MIPs), which play a major role in allorecognition. On the basis of comprehensive analyses of the genomic landscape of...
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