Article
Compromised calnexin function in calreticulin-deficient cells.
Biochemical and biophysical research communications - 16 May 2003
Knee Rai, Ahsan Irfan, Mesaeli Nasrin, Kaufman Randal J, Michalak Marek
Abstract excerpt
Calnexin and calreticulin are molecular chaperones, which are involved in the protein folding, assembly, and retention/retrieval. We know that calreticulin-deficiency is lethal in utero, but do not understand the contribution of chaperone function to this phenotype. Here we studied protein folding and chaperone function of calnexin in the absence of calreticulin. We show that protein folding is accelerated and...
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