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Article

Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity.

The FEBS journal - 1 Nov 2011

Bence Melinda, Sahin-Tóth Miklós

Abstract excerpt

Human chymotrypsin C (CTRC) plays a protective role in the pancreas by mitigating premature trypsinogen activation through degradation. Mutations that abolish activity or secretion of CTRC increase the risk for chronic pancreatitis. The aim of the present study was to determine whether human CTRC undergoes asparagine-linked (N-linked) glycosylation and to examine the role of this modification in CTRC folding and...

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Source

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Identifiers

PMID: 21920023
DOI: 10.1111/j.1742-4658.2011.08351.x
PMCID: PMC3209518

Genes

CTRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity.PMID 21920023Read ↗

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