Article
N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic.
The Journal of cell biology - 23 Mar 2009
Glozman Rina, Okiyoneda Tsukasa, Mulvihill Cory M, Rini James M, Barriere Herve, Lukacs Gergely L
Abstract excerpt
N-glycosylation, a common cotranslational modification, is thought to be critical for plasma membrane expression of glycoproteins by enhancing protein folding, trafficking, and stability through targeting them to the ER folding cycles via lectin-like chaperones. In this study, we show that N-glycans, specifically core glycans, enhance the productive folding and conformational stability of a polytopic membrane...
Topics
- Animals
- COS Cells
- Cell Membrane
- Chlorocebus aethiops
- Cricetinae
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA-Binding Proteins
- Endocytosis
- Endosomal Sorting Complexes Required for Transport
- Endosomes
- Glycosylation
- Humans
- Lysosomes