Article

Exploring the Landscape of Ectodomain Shedding by Quantitative Protein Terminomics

2020-09-24

Abstract excerpt

Ectodomain shedding is a proteolytic process that regulates the levels and functions of membrane proteins. Dysregulated shedding is linked to severe diseases, including cancer and Alzheimer’s disease. However, the exact cleavage sites of shedding substrates remain largely unknown. Here, we explore the landscape of ectodomain shedding by generating large-scale, cell-type-specific maps of shedding cleavage sites. By...

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Literature Corpus work: 9d6c23df-15d8-5262-8542-30d8d06316e6
DOI: 10.1101/2020.09.23.310102

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