Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.

Molecular cell - 7 Jun 2018

Dovey Cole M, Diep Jonathan, Clarke Bradley P, Hale Andrew T, McNamara Dan E, Guo Hongyan, Brown Nathaniel W, Cao Jennifer Yinuo, Grace Christy R, Gough Peter J, Bertin John, Dixon Scott J, Fiedler Dorothea, Mocarski Edward S, Kaiser William J, Moldoveanu Tudor, York John D, Carette Jan E

Abstract excerpt

Necroptosis is an important form of lytic cell death triggered by injury and infection, but whether mixed lineage kinase domain-like (MLKL) is sufficient to execute this pathway is unknown. In a genetic selection for human cell mutants defective for MLKL-dependent necroptosis, we identified mutations in IPMK and ITPK1, which encode inositol phosphate (IP) kinases that regulate the IP code of soluble molecules. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 1, Human

Share to HT29 Cells

Share to Inositol Phosphates

Share to Jurkat Cells

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Receptor-Interacting Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 29883610
DOI: 10.1016/j.molcel.2018.05.010
PMCID: PMC5994928

Genes

MLKL
IPMK
ITPK1
RIPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.PMID 29883610Read ↗

The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL).Semantic proximity Read ↗

Post-translational control of RIPK3 and MLKL mediated necroptotic cell deathSemantic proximity Read ↗

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.Semantic proximity Read ↗

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.Semantic proximity Read ↗

Necroptosis: a crucial pathogenic mediator of human diseaseSemantic proximity Read ↗

Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulatorsSemantic proximity Read ↗

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.Semantic proximity Read ↗

Inositol pyrophosphates as mammalian cell signals.Semantic proximity Read ↗

The Role of the Key Effector of Necroptotic Cell Death, Mlkl, in Mouse Models of DiseaseSemantic proximity Read ↗

The Role of the Key Effector of Necroptotic Cell Death, MLKL, in Mouse Models of DiseaseSemantic proximity Read ↗

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKLSemantic proximity Read ↗

TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.