Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.

Proceedings of the National Academy of Sciences of the United States of America - 21 Oct 2014

Hildebrand Joanne M, Tanzer Maria C, Lucet Isabelle S, Young Samuel N, Spall Sukhdeep K, Sharma Pooja, Pierotti Catia, Garnier Jean-Marc, Dobson Renwick C J, Webb Andrew I, Tripaydonis Anne, Babon Jeffrey J, Mulcair Mark D, Scanlon Martin J, Alexander Warren S, Wilks Andrew F, Czabotar Peter E, Lessene Guillaume, Murphy James M, Silke John

Abstract excerpt

Necroptosis is considered to be complementary to the classical caspase-dependent programmed cell death pathway, apoptosis. The pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) is an essential effector protein in the necroptotic cell death pathway downstream of the protein kinase Receptor Inte...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Amino Acid Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Inhibitory Concentration 50

Share to Necrosis

Share to Protein Kinases

Share to Protein Structure, Secondary

Share to Receptor-Interacting Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 25288762
DOI: 10.1073/pnas.1408987111
PMCID: PMC4210347

Genes

MLKL
RIPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25288762-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.PMID 25288762Read ↗

The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL).Semantic proximity Read ↗

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.Semantic proximity Read ↗

Post-translational control of RIPK3 and MLKL mediated necroptotic cell deathSemantic proximity Read ↗

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.Semantic proximity Read ↗

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation.Semantic proximity Read ↗

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitisSemantic proximity Read ↗

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced ApoptosisSemantic proximity Read ↗

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKLSemantic proximity Read ↗

Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulatorsSemantic proximity Read ↗

The Role of the Key Effector of Necroptotic Cell Death, Mlkl, in Mouse Models of DiseaseSemantic proximity Read ↗

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes NecroptosisSemantic proximity Read ↗

The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.