Article
Cytogenetic changes induced in human diploid fibroblasts by tsA58 SV40 at permissive and restrictive temperatures.
Mutation research - 1 Jan 2000
Nichols W W, Girardi A J, Bradt C I, Hill R, Cody C
Abstract excerpt
Human diploid fibroblasts have been transformed by ts A58 SV40. At the permissive temperature, apparent chromosome and chromatic rearrangements were observed in a high percentage of cells and the frequency of SCE increased. If the transformed phenotype returned to normal at the restrictive temperature these alterations also returned to normal levels. Chromosome banding demonstrated many apparent chromosomal...
Topics
- Cell Transformation, Viral
- Cells, Cultured
- Chromosome Aberrations
- Humans
- Mutation
- Simian virus 40
- Sister Chromatid Exchange
- Temperature