Article
Repositioning of human interphase chromosomes by nucleolar dynamics in the reverse transformation of HT1080 fibrosarcoma cells.
Experimental cell research - 25 May 1998
Krystosek A
Abstract excerpt
An experimental system which should be valuable for studying the role of spatial positioning of the nuclear genome in human cell function has been developed. Reverse transformation of the malignant HT1080 fibrosarcoma cell line upon treatment with 8-chloro-cAMP results in growth inhibition, cytos...
Topics
- 8-Bromo Cyclic Adenosine Monophosphate
- Binding Sites
- Cell Division
- Cell Nucleolus
- Cell Transformation, Neoplastic
- Chromosome Mapping
- Chromosomes
- DNA Probes
- Fibrosarcoma
- Humans
- In Situ Hybridization, Fluorescence
- Interphase
- Kinetochores
- Phenotype
- Repetitive Sequences, Nucleic Acid
- Tumor Cells, Cultured