Investigations in the transforming activity of temperature-sensitive mutants of herpes simplex virus.

Article

Investigations in the transforming activity of temperature-sensitive mutants of herpes simplex virus.

Virologie - 1 Jan 2000

Danielescu G, Baba C, Cajal N, Anton D, Botnariuc I, Constantinescu O, Muţiu A

Abstract excerpt

Transformation of rat embryo fibroblast was induced by a temperature-sensitive mutant of herpes simplex virus type 2. Transformation was scored using the morphological criterion of focus formation and the cell changes that lead to the final focus are described. Virus genome persistence in the tra...

Topics

Animals
Antigens, Viral
Cell Transformation, Viral
Cells, Cultured
Chromosomes
Fibroblasts
Humans
Mutation
Rabbits
Rats
Rats, Inbred Strains
Simplexvirus
Temperature

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