Induction of tetraploid DNA content by simian virus 40 is dependent on T-antigen function in the G2 phase of the cell cycle.

doi:10.1128/JVI.68.6.4028-4030.1994

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Article

Induction of tetraploid DNA content by simian virus 40 is dependent on T-antigen function in the G2 phase of the cell cycle.

Journal of virology - 1 Jun 1994

Friedrich T D, Laffin J, Lehman J M

Abstract excerpt

Previous experiments with the simian virus 40 mutant tsA357R-K (tsA30) demonstrated a T-antigen function that is required for production of cells with a greater-than-G2-phase DNA content. In this study, temperature shift experiments indicated that the temperature-sensitive function of tsA357R-K,...

Topics

Animals
Antigens, Viral, Tumor
Cell Line
DNA
G2 Phase
Mutation
Papillomavirus Infections
Polyploidy
Simian virus 40
Temperature
Tumor Virus Infections

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