Murine temperature-sensitive DNA polymerase alpha mutant displays a diminished capacity to stimulate DNA synthesis in senescent human fibroblast nuclei in heterokaryons at the nonpermissive condition.

Abstract excerpt

We have investigated the capacity of a murine cell line with a temperature-sensitive (ts) mutation in the DNA polymerase alpha (Pola) locus and a series of ts non-Pola mutant cell lines from separate complementation groups to stimulate DNA synthesis, in senescent fibroblast nuclei in heterokaryons. In the Pola mutant x senescent heterodikaryons, both human and murine nuclei display significantly diminished levels...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Line
• Share to Cell Nucleus