Murine temperature-sensitive DNA polymerase alpha mutant displays a diminished capacity to stimulate DNA synthesis in senescent human fibroblast nuclei in heterokaryons at the nonpermissive condition.

Abstract excerpt

We have investigated the capacity of a murine cell line with a temperature-sensitive (ts) mutation in the DNA polymerase alpha (Pola) locus and a series of ts non-Pola mutant cell lines from separate complementation groups to stimulate DNA synthesis, in senescent fibroblast nuclei in heterokaryon...

Topics

• Animals
• Autoradiography
• Cell Fusion
• Cell Line
• Cell Nucleus
• Cellular Senescence
• DNA
• DNA Polymerase II
• Fibroblasts
• Humans
• Karyotyping
• Mice