Article
The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 May 2015
Gollapudi B Bhaskar, Lynch Anthony M, Heflich Robert H, Dertinger Stephen D, Dobrovolsky Vasily N, Froetschl Roland, Horibata Katsuyoshi, Kenyon Michelle O, Kimoto Takafumi, Lovell David P, Stankowski Leon F, White Paul A, Witt Kristine L, Tanir Jennifer Y
Abstract excerpt
The in vivo Pig-a assay uses flow cytometry to measure phenotypic variants for antibody binding to cell surface glycosylphosphatidylinositol (GPI)-anchored proteins. There is good evidence suggesting that the absence of antibody binding is the result of a mutation in the endogenous X-linked Pig-a gene, which forms the rationale for the assay. Although the assay has been performed with several types of...
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