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Article

Combined Drug Resistance Mutations Substantially Enhance Enzyme Production in Paenibacillus agaridevorans.

Journal of bacteriology - 1 Sept 2018

Funane Kazumi, Tanaka Yukinori, Hosaka Takeshi, Murakami Kiriko, Miyazaki Takatsugu, Shiwa Yuh, Gibu Shigehachi, Inaoka Takashi, Kasahara Ken, Fujita Nobuyuki, Yoshikawa Hirofumi, Hiraga Yoshikazu, Ochi Kozo

Abstract excerpt

This study shows that sequential introduction of drug resistance mutations substantially increased enzyme production in Paenibacillus agaridevorans The triple mutant YT478 (rsmG Gln225→stop codon, rpsL K56R, and rpoB R485H), generated by screening for resistance to streptomycin and rifampin, expressed a 1,100-fold-larger amount of the extracellular enzyme cycloisomaltooligosaccharide glucanotransferase (CITase)...

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Source

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Identifiers

PMID: 29866810
DOI: 10.1128/JB.00188-18
PMCID: PMC6088162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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