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Article

Activation of Antibiotic Production in Bacillus spp. by Cumulative Drug Resistance Mutations.

Antimicrobial agents and chemotherapy - 1 Dec 2015

Tojo Shigeo, Tanaka Yukinori, Ochi Kozo

Abstract excerpt

Bacillus subtilis strains produce a wide range of antibiotics, including ribosomal and nonribosomal peptide antibiotics, as well as bacilysocin and neotrehalosadiamine. Mutations in B. subtilis strain 168 that conferred resistance to drugs such as streptomycin and rifampin resulted in overproduction of the dipeptide antibiotic bacilysin. Cumulative drug resistance mutations, such as mutations in the mthA and rpsL...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26369962
DOI: 10.1128/AAC.01932-15
PMCID: PMC4649196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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