Article
Integrated genomic-transcriptomic analysis of clavulanic acid production in differentially productive Streptomyces clavuligerus strains.
Scientific reports - 27 Nov 2025
Gong Junpyo, Yi Jeong Sang, An Seungchan, Cho Hang Su, Shin Chang Hun, Won Hyung-Jin, Lee Namil, Lee Yongjae, Cho Byung-Kwan, Noh Minsoo, Yoon Yeo Joon
Abstract excerpt
Clavulanic acid (CA) is a specific metabolite that inhibits β-lactamases, which inactivate β-lactam antibiotics, therefore reinstating the activity of β-lactams against β-lactamase-producing pathogens, and surmounting β-lactam resistance. While extensive efforts have been made to optimize CA production through random mutagenesis, these approaches often introduce deleterious mutations, limiting further yield...
Topics
- Streptomyces
- Clavulanic Acid
- Gene Expression Profiling
- Genomics
- Gene Expression Regulation, Bacterial
- Transcriptome
- Mutation
- Genome, Bacterial
- Biosynthetic Pathways
- Mutagenesis