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Article

Integrated genomic-transcriptomic analysis of clavulanic acid production in differentially productive Streptomyces clavuligerus strains.

Scientific reports - 27 Nov 2025

Gong Junpyo, Yi Jeong Sang, An Seungchan, Cho Hang Su, Shin Chang Hun, Won Hyung-Jin, Lee Namil, Lee Yongjae, Cho Byung-Kwan, Noh Minsoo, Yoon Yeo Joon

Abstract excerpt

Clavulanic acid (CA) is a specific metabolite that inhibits β-lactamases, which inactivate β-lactam antibiotics, therefore reinstating the activity of β-lactams against β-lactamase-producing pathogens, and surmounting β-lactam resistance. While extensive efforts have been made to optimize CA production through random mutagenesis, these approaches often introduce deleterious mutations, limiting further yield...

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Identifiers

PMID: 41310174
DOI: 10.1038/s41598-025-29509-x
PMCID: PMC12749726

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