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Article

Activation and products of the cryptic secondary metabolite biosynthetic gene clusters by rifampin resistance (rpoB) mutations in actinomycetes.

Journal of bacteriology - 1 Jul 2013

Tanaka Yukinori, Kasahara Ken, Hirose Yutaka, Murakami Kiriko, Kugimiya Rie, Ochi Kozo

Abstract excerpt

A subset of rifampin resistance (rpoB) mutations result in the overproduction of antibiotics in various actinomycetes, including Streptomyces, Saccharopolyspora, and Amycolatopsis, with H437Y and H437R rpoB mutations effective most frequently. Moreover, the rpoB mutations markedly activate (up to 70-fold at the transcriptional level) the cryptic/silent secondary metabolite biosynthetic gene clusters of these...

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Identifiers

PMID: 23603745
DOI: 10.1128/JB.00147-13
PMCID: PMC3697537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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