Article
Genome-wide epistasis analysis for Alzheimer's disease and implications for genetic risk prediction.
Alzheimer's research & therapy - 4 Mar 2021
Wang Hui, Bennett David A, De Jager Philip L, Zhang Qing-Ye, Zhang Hong-Yu
Abstract excerpt
BACKGROUND: Single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies only explain part of the heritability of Alzheimer's disease (AD). Epistasis has been considered as one of the main causes of "missing heritability" in AD. METHODS: We performed genome-wide epistasis screening (N = 10,389) for the clinical diagnosis of AD using three popularly adopted methods. Subsequent analyses were...
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