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Article

Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells.

Journal of autoimmunity - 1 Aug 2018

Kim Yong Chan, Zhang Ai-Hong, Yoon Jeongheon, Culp William E, Lees Jason R, Wucherpfennig Kai W, Scott David W

Abstract excerpt

Expanded polyclonal T regulatory cells (Tregs) offer great promise for the treatment of immune-mediated diseases. Inhibition by Tregs is under the control of the T-cell receptor (TCR). Therefore, we created Tregs with defined antigen specificity, using a recombinant T-cell receptor isolated from a myelin-basic protein specific T-cell clone of a multiple sclerosis (MS) patient (Ob2F3). We expressed this TCR using...

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Share to Bystander Effect
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DR Serological Subtypes

Share to Immunotherapy, Adoptive

Share to Interleukin-2

Share to Myelin Basic Protein

Share to Myelin-Oligodendrocyte Glycoprotein

Share to T-Cell Antigen Receptor Specificity

Source

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Identifiers

PMID: 29857928
DOI: 10.1016/j.jaut.2018.05.003
PMCID: PMC6054915

Genes

MBP
MOG
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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