Engineered antigen-specific T regulatory cells suppress autoreactivity to the anti-glomerular basement membrane disease antigen.

doi:10.1016/j.kint.2025.01.005

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Article

Engineered antigen-specific T regulatory cells suppress autoreactivity to the anti-glomerular basement membrane disease antigen.

Kidney international - 1 Apr 2025

Eggenhuizen Peter J, Ng Boaz H, Lo Cecilia, Chang Janet, Snelgrove Sarah L, Cheong Rachel M Y, Shen Chanjuan, Lim Steven, Zhong Yong, Gan Poh-Yi, Ooi Joshua D

Abstract excerpt

Anti-glomerular basement membrane (anti-GBM) disease is accompanied by insufficient antigen-specific regulatory T cells (Tregs) and clonally expanded antigen-specific conventional T cells. In particular, this applied to the immunodominant T cell autoepitope of type IV collagen, α3(IV)NC1135-145, presented by human leukocyte antigen-DRB1∗1501. Here, we investigated whether Tregs engineered to express GBM-T cell...

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Topics

T-Lymphocytes, Regulatory
Anti-Glomerular Basement Membrane Disease
Humans
Collagen Type IV
Autoimmunity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals

Autoantigens

Dendritic Cells

Phenotype

Receptors, Chimeric Antigen

B-Lymphocytes

Immune Tolerance

Receptors, Antigen, T-Cell

Source

Open in PubMed

Identifiers

PMID: 39842638
DOI: 10.1016/j.kint.2025.01.005

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