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Article

Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer

22 Jul 2010

Abstract excerpt

BACKGROUND: Therapies directed at augmenting regulatory T cell (Treg) activities in vivo as a systemic treatment for autoimmune disorders and transplantation may be associated with significant off-target effects, including a generalized immunosuppression that may compromise beneficial immune responses to infections and cancer cells. Adoptive cellular therapies using purified expanded Tregs represents an...

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PMID: 20668510
DOI: 10.1371/journal.pone.0011726

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