Genome-wide meta-analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans.

doi:10.1002/mgg3.788

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Article

Genome-wide meta-analysis of SNP and antihypertensive medication interactions on left ventricular traits in African Americans.

Molecular genetics & genomic medicine - 1 Oct 2019

Do Anh N, Zhao Wei, Baldridge Abigail S, Raffield Laura M, Wiggins Kerri L, Shah Sanjiv J, Aslibekyan Stella, Tiwari Hemant K, Limdi Nita, Zhi Degui, Sitlani Colleen M, Taylor Kent D, Psaty Bruce M, Sotoodehnia Nona, Brody Jennifer A, Rasmussen-Torvik Laura J, Lloyd-Jones Donald, Lange Leslie A, Wilson James G, Smith Jennifer A, Kardia Sharon L R, Mosley Thomas H, Vasan Ramachandran S, Arnett Donna K, Irvin Marguerite R

Abstract excerpt

BACKGROUND: Left ventricular (LV) hypertrophy affects up to 43% of African Americans (AAs). Antihypertensive treatment reduces LV mass (LVM). However, interindividual variation in LV traits in response to antihypertensive treatments exists. We hypothesized that genetic variants may modify the association of antihypertensive treatment class with LV traits measured by echocardiography. METHODS: We evaluated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31407531
DOI: 10.1002/mgg3.788
PMCID: PMC6785453

Genes

ACE
BICD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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