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Article

Activation of the mismatch-specific endonuclease EndoMS/NucS by the replication clamp is required for high fidelity DNA replication.

Nucleic acids research - 6 Jul 2018

Ishino Sonoko, Skouloubris Stéphane, Kudo Hanae, l'Hermitte-Stead Caroline, Es-Sadik Asmae, Lambry Jean-Christophe, Ishino Yoshizumi, Myllykallio Hannu

Abstract excerpt

The mismatch repair (MMR) system, exemplified by the MutS/MutL proteins, is widespread in Bacteria and Eukarya. However, molecular mechanisms how numerous archaea and bacteria lacking the mutS/mutL genes maintain high replication fidelity and genome stability have remained elusive. EndoMS is a recently discovered hyperthermophilic mismatch-specific endonuclease encoded by nucS in Thermococcales. We deleted the...

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PMID: 29846672
DOI: 10.1093/nar/gky460
PMCID: PMC6159515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Activation of the mismatch-specific endonuclease EndoMS/NucS by the replication clamp is required for high fidelity DNA replication.PMID 29846672Read ↗

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