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Article

Correction of non-random mutational biases along a linear bacterial chromosome by the mismatch repair endonuclease NucS.

Nucleic acids research - 22 May 2024

Dagva Oyut, Thibessard Annabelle, Lorenzi Jean-Noël, Labat Victor, Piotrowski Emilie, Rouhier Nicolas, Myllykallio Hannu, Leblond Pierre, Bertrand Claire

Abstract excerpt

The linear chromosome of Streptomyces exhibits a highly compartmentalized structure with a conserved central region flanked by variable arms. As double strand break (DSB) repair mechanisms play a crucial role in shaping the genome plasticity of Streptomyces, we investigated the role of EndoMS/NucS, a recently characterized endonuclease involved in a non-canonical mismatch repair (MMR) mechanism in archaea and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38444149
DOI: 10.1093/nar/gkae132
PMCID: PMC11109965

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Correction of non-random mutational biases along a linear bacterial chromosome by the mismatch repair endonuclease NucS.PMID 38444149Read ↗

Control of Genome Stability by EndoMS/NucS-Mediated Non-Canonical Mismatch RepairSemantic proximity Read ↗

Bacterial EndoMS/NucS acts as a clamp-mediated mismatch endonuclease to prevent asymmetric accumulation of replication errors.Semantic proximity Read ↗

The unique role of nucS-mediated noncanonical mismatch repair in Mycobacterium tuberculosis resistance evolution.Semantic proximity Read ↗

Activation of the mismatch-specific endonuclease EndoMS/NucS by the replication clamp is required for high fidelity DNA replication.Semantic proximity Read ↗

The unique role of <i>nucS</i> -mediated non-canonical mismatch repair in <i>Mycobacterium tuberculosis</i> resistance evolutionSemantic proximity Read ↗

Regulation of the expression of <i>nucS</i> , a key component of mismatch repair system in mycobacteriaSemantic proximity Read ↗

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Transcriptional Response of Streptomyces coelicolor to Rapid Chromosome Relaxation or Long-Term Supercoiling ImbalanceSemantic proximity Read ↗

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