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Control of Genome Stability by EndoMS/NucS-Mediated Non-Canonical Mismatch Repair

25 May 2021

Abstract excerpt

The DNA repair endonuclease EndoMS/NucS is highly conserved in Archaea and Actinobacteria. This enzyme is able to recognize and cleave dsDNA carrying a mismatched base pair, and its activity is enhanced by the interaction with the sliding clamp of the replisome. Today, EndoMS/NucS has been established as the key protein of a non-canonical mismatch repair (MMR) pathway, acting specifically in the repair of...

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PMID: 34070467
DOI: 10.3390/cells10061314

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