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The unique role of <i>nucS</i> -mediated non-canonical mismatch repair in <i>Mycobacterium tuberculosis</i> resistance evolution

2025-06-19

Abstract excerpt

DNA surveillance mechanisms play a vital role in maintaining genome stability and minimizing mutation rates. One such mechanism, post-replicative mismatch repair (MMR), corrects replication errors that escape DNA polymerase proofreading activity. In most bacteria and eukaryotes, MMR is orchestrated by MutS and MutL proteins. However, certain archaeal and actinobacterial species, including the major human pathogen...

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Literature Corpus work
c9846cb4-0266-56e6-b4f2-142a04c6c239
DOI
10.1101/2025.06.19.660520
Open publication

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The unique role of <i>nucS</i> -mediated non-canonical mismatch repair in <i>Mycobacterium tuberculosis</i> resistance evolutionDOI 10.1101/2025.06.19.660520
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