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Regulation of the expression of <i>nucS</i> , a key component of mismatch repair system in mycobacteria

2025-07-25

Abstract excerpt

<h4>ABSTRACT</h4> Alterations in the expression of the mismatch repair (MMR) system can lead to transient hypermutation, accelerating the emergence of adaptive mutations under stress conditions, such as antibiotic pressure. While most bacteria and eukaryotes rely on the MutS and MutL protein families for MMR, many archaeal and actinobacterial species, including the major human pathogen Mycobacterium tuberculosis...

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Literature Corpus work
65f5d357-76a1-5d51-87f2-201347c3e15a
DOI
10.1101/2025.07.23.666449
Open publication

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