Article
Identification of a mismatch-specific endonuclease in hyperthermophilic Archaea.
Nucleic acids research - 20 Apr 2016
Ishino Sonoko, Nishi Yuki, Oda Soichiro, Uemori Takashi, Sagara Takehiro, Takatsu Nariaki, Yamagami Takeshi, Shirai Tsuyoshi, Ishino Yoshizumi
Abstract excerpt
The common mismatch repair system processed by MutS and MutL and their homologs was identified in Bacteria and Eukarya. However, no evidence of a functional MutS/L homolog has been reported for archaeal organisms, and it is not known whether the mismatch repair system is conserved in Archaea. Here, we describe an endonuclease that cleaves double-stranded DNA containing a mismatched base pair, from the...
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