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Article

Engineering of the DNA replication and repair machinery to develop binary mutators for rapid genome evolution of Corynebacterium glutamicum.

Nucleic acids research - 8 Sept 2023

Cai Ningyun, Chen Jiuzhou, Gao Ning, Ni Xiaomeng, Lei Yu, Pu Wei, Wang Lixian, Che Bin, Fan Liwen, Zhou Wenjuan, Feng Jinhui, Wang Yu, Zheng Ping, Sun Jibin

Abstract excerpt

Corynebacterium glutamicum is an important industrial workhorse for production of amino acids and chemicals. Although recently developed genome editing technologies have advanced the rational genetic engineering of C. glutamicum, continuous genome evolution based on genetic mutators is still unavailable. To address this issue, the DNA replication and repair machinery of C. glutamicum was targeted in this study....

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Identifiers

PMID: 37449409
DOI: 10.1093/nar/gkad602
PMCID: PMC10484736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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