Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.

Blood - 26 Jul 2018

Melo-Cardenas Johanna, Xu Yuanming, Wei Juncheng, Tan Can, Kong Sinyi, Gao Beixue, Montauti Elena, Kirsammer Gina, Licht Jonathan D, Yu Jindan, Ji Peng, Crispino John D, Fang Deyu

Abstract excerpt

Ras mutations are commonly observed in juvenile myelomonocytic leukemia (JMML) and chronic myelomonocytic leukemia (CMML). JMML and CMML transform into acute myeloid leukemia (AML) in about 10% and 50% of patients, respectively. However, how additional events cooperate with Ras to promote this transformation are largely unknown. We show that absence of the ubiquitin-specific peptidase 22 (USP22), a component of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid

Share to Leukemia, Myelomonocytic, Juvenile

Share to Proto-Oncogene Proteins p21(ras)

Share to Survival Rate

Share to Trans-Activators

Share to Ubiquitin Thiolesterase

Source

Open in PubMed Open full text

Identifiers

PMID: 29844011
DOI: 10.1182/blood-2017-10-811760
PMCID: PMC6071563

Genes

USP22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.PMID 29844011Read ↗

Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in CancerSemantic proximity Read ↗

Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cellsSemantic proximity Read ↗

The emerging role of ubiquitin-specific protease 20 in tumorigenesis and cancer therapeuticsSemantic proximity Read ↗

Roles of USP9X in cellular functions and tumorigenesis (Review)Semantic proximity Read ↗

Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.Semantic proximity Read ↗

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.Semantic proximity Read ↗

c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitroSemantic proximity Read ↗

USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer ProgressionSemantic proximity Read ↗

USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitinationSemantic proximity Read ↗

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.Semantic proximity Read ↗

USP18 regulates the malignant phenotypes of glioblastoma stem cells.Semantic proximity Read ↗

TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant HematopoiesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.