Article
The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.
The Journal of clinical investigation - 1 Aug 2014
Diefenbacher Markus E, Popov Nikita, Blake Sophia M, Schülein-Völk Christina, Nye Emma, Spencer-Dene Bradley, Jaenicke Laura A, Eilers Martin, Behrens Axel
Abstract excerpt
Colorectal cancer is the third most common cancer worldwide. Although the transcription factor c-MYC is misregulated in the majority of colorectal tumors, it is difficult to target directly. The deubiquitinase USP28 stabilizes oncogenic factors, including c-MYC; however, the contribution of USP28 in tumorigenesis, particularly in the intestine, is unknown. Here, using murine genetic models, we determined that...
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